منابع مشابه
Prolactin Secreting Pituitary Adenomas
Correspondence to: Ioana Muntean, e-mail: [email protected] ABSTRACT. Hyperprolactinemia has different etiologic forms, among them, the prolactin-secreting pituitary tumors represent an important entity. In our study, were analyzed the clinical aspects, diagnostic procedures and therapeutical approach of 31 cases of prolactinomas (F/M ratio = 27/4) hospitalized in the Clinic of Endocrinol...
متن کاملSynchronous GH- and prolactin-secreting pituitary adenomas
UNLABELLED Pituitary adenomas are usually solitary lesions. Rarely, patients may present with two distinct pituitary tumors. We report a case of synchronous secretory pituitary adenomas in a woman who initially presented with elevated prolactin levels. She was initially treated with cabergoline, but, after many years, she began developing symptoms consistent with acromegaly. Imaging revealed tw...
متن کاملStereotactic Irradiation of GH-Secreting Pituitary Adenomas
Radiotherapy (RT) is often employed in patients with acromegaly refractory to medical and/or surgical interventions in order to prevent tumour regrowth and normalize elevated GH and IGF-I levels. It achieves tumour control and hormone normalization up to 90% and 70% of patients at 10-15 years. Despite the excellent tumour control, conventional RT is associated with a potential risk of developin...
متن کاملLandscape of somatic mutations in sporadic GH-secreting pituitary adenomas.
CONTEXT Alterations in the cAMP signaling pathway are common in hormonally active endocrine tumors. Somatic mutations at GNAS are causative in 30-40% of GH-secreting adenomas. Recently, mutations affecting the USP8 and PRKACA gene have been reported in ACTH-secreting pituitary adenomas and cortisol-secreting adrenocortical adenomas respectively. However, the pathogenesis of many GH-secreting ad...
متن کاملProlactin-secreting pituitary adenomas: correlation of radiographic and surgical findings.
The preoperative hypocycloidal sellar tomograms, angiograms, and pneumoencephalograms of 100 patients being evaluated for prolactin-secreting pituitary adenomas were reviewed and the results correlated with surgical findings at transsphenoidal exploration. The majority (53%) of tumors encountered were microadenomas. Although sellar volume was normal in 72%, sellar shape on tomography was abnorm...
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ژورنال
عنوان ژورنال: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
سال: 1990
ISSN: 0317-1671,2057-0155
DOI: 10.1017/s0317167100030043